Summary | Transgene origin | Transgene description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Cyp21a1-Apoe)619Fet
Name:	transgene insertion 619, Fayanne Thorngate
MGI ID:	MGI:3822316
Synonyms:	Line 619
Transgene:	Tg(Cyp21a1-Apoe)619Fet  Location: unknown
Alliance:	Tg(Cyp21a1-Apoe)619Fet page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Cyp21a1-Apoe)619Fet expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Apoe (MGI:88057)   Mutation details: A construct containing approximately 6 kb of the mouse Cyp21a1 promoter attached to the mouse Apoe gene was used for injection into fertilized FVB/N oocytes. Ten independent founder lines were generated. Line 619 was donated to the Jackson Laboratory and is representative of low expressing Apoe lines (lines 619 and 620). Only adrenal expression of Apoe was detected for these lines with Line 619 having the lowest mRNA expression (1.6 pg Apoe mRNA per microgram of total RNA). Mice have only 1-2% of wild-type plasma Apoe protein level. (J:130658)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:130658 Thorngate FE, et al., Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2000 Aug;20(8):1939-45
All:	3 reference(s)