Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Myh6-Ptpn11*Q79R)197Rbns
Name:	transgene insertion 197, Jeffrey Robbins
MGI ID:	MGI:3822133
Synonyms:	alpha-MHC-Q97R197
Transgene:	Tg(Myh6-Ptpn11*Q79R)197Rbns  Location: unknown
Alliance:	Tg(Myh6-Ptpn11*Q79R)197Rbns page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Myh6-Ptpn11*Q79R)197Rbns expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Ptpn11 (MGI:99511) Transgene codes for a protein with a glutamin to arginine mutation.   Mutation details: The promoter was used to drive expression of Ptpn11 containing the amino acid substitution of arginine for glutamine at position 79 in the postnatal heart. This mutation results in an increase in phosphatase activity. Several lines were created and line 197 was used in subsequent experiments. (J:123963)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:123963 Nakamura T, et al., Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. J Clin Invest. 2007 Aug;117(8):2123-32
All:	1 reference(s)