Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Snap25tm1.1Bark
Name:	synaptosomal-associated protein 25; targeted mutation 1.1, Christina Bark
MGI ID:	MGI:3821974
Gene:	Snap25  Location: Chr2:136555373-136624348 bp, + strand  Genetic Position: Chr2, 67.56 cM
Alliance:	Snap25tm1.1Bark page

Germline Transmission:	Earliest citation of germline transmission: J:142096
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 5b was replaced with the sequence for an additional exon5a. A floxed cre cassette used for selection purposes was inserted into intron 5 and removed by germ line, cre mediated recombination. The lack of B isoform mRNA was confirmed by semi-quantitative PCR while the overall protein expression level from this gene was slightly increased as determined by protein quantitation. (J:142096)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snap25 Mutation:	26 strains or lines available

Original:	J:142096 Johansson JU, et al., An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function. PLoS Genet. 2008 Nov;4(11):e1000278
All:	6 reference(s)