Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ncor1tm1Anh
Name:	nuclear receptor co-repressor 1; targeted mutation 1, Anthony N Hollenberg
MGI ID:	MGI:3821874
Synonyms:	NCoRlox
Gene:	Ncor1  Location: Chr11:62207132-62348200 bp, - strand  Genetic Position: Chr11, 38.08 cM, cytoband B2
Alliance:	Ncor1tm1Anh page

Germline Transmission:	Earliest citation of germline transmission: J:142045
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 38 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 41. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 38 through 41 floxed. These exons encode two of the three receptor interacting domains (N2 and N3). (J:142045)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncor1 Mutation:	394 strains or lines available

Original:	J:142045 Astapova I, et al., The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19544-9
All:	13 reference(s)