Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Zbtb7btm1.1Litt
Name:	zinc finger and BTB domain containing 7B; targeted mutation 1.1, Dan R Littman
MGI ID:	MGI:3821618
Synonyms:	ThPOKF
Gene:	Zbtb7b  Location: Chr3:89284953-89300976 bp, - strand  Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
Alliance:	Zbtb7btm1.1Litt page

Germline Transmission:	Earliest citation of germline transmission: J:141144
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	B6(Cg)-Tyrc-2J/J

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Intragenic deletion   Mutation details: Transient cre recombinase expression in embryonic stem cells containing the Zbtb7btm1Litt allele removed the neomycin resistance cassette and left the entire coding sequence of the gene locus flanked by loxP sites. (J:141144)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zbtb7b Mutation:	24 strains or lines available

Original:	J:141144 Egawa T, et al., ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol. 2008 Oct;9(10):1131-9
All:	3 reference(s)