Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Postntm1Jmol
Name:	periostin, osteoblast specific factor; targeted mutation 1, Jeffery D Molkentin
MGI ID:	MGI:3819350
Synonyms:	Pn-
Gene:	Postn  Location: Chr3:54268530-54298458 bp, + strand  Genetic Position: Chr3, 25.46 cM
Alliance:	Postntm1Jmol page

Germline Transmission:	Earliest citation of germline transmission: J:140301
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 through 10 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on P1 developing foot and heart extracts. (J:140301)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Postntm1Jmol

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Postn Mutation:	52 strains or lines available

Original:	J:140301 Oka T, et al., Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res. 2007 Aug 3;101(3):313-21
All:	32 reference(s)