Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Rettm1Giro
Name:	ret proto-oncogene; targeted mutation 1, Giovanni Romeo
MGI ID:	MGI:3819163
Synonyms:	retC620R
Gene:	Ret  Location: Chr6:118128706-118174679 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance:	Rettm1Giro page

Germline Transmission:	Earliest citation of germline transmission: J:141658
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted Mutations:    Insertion, Nucleotide substitutions   Mutation details: Nucleotide substitutions were used to create an amino acid substitution of arginnine for cysteine at position 20 (C620R). A floxed neo cassette inserted downstream of exon 10 was removed by transient cre expression in ES cells. (J:141658)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Rettm1Giro

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:	53 strains or lines available

Original:	J:141658 Yin L, et al., C620R mutation of the murine ret proto-oncogene: loss of function effect in homozygotes and possible gain of function effect in heterozygotes. Int J Cancer. 2007 Jul 15;121(2):292-300
All:	2 reference(s)