Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Senp2Gt(AN0727)Wtsi
Name:	SUMO/sentrin specific peptidase 2; gene trap AN0727, Wellcome Trust Sanger Institute
MGI ID:	MGI:3818535
Gene:	Senp2  Location: Chr16:21828234-21868019 bp, + strand  Genetic Position: Chr16, 12.98 cM, cytoband B1
Alliance:	Senp2Gt(AN0727)Wtsi page

Mutant Cell Line:	AN0727
Germline Transmission:	Earliest citation of germline transmission: J:141453
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Sanger Inst. Gene Trap Res.

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: pGT0lxr     The gene trap vector pGT01xr, which contains a beta-geo cassette, was inserted into intron 10. (J:141453) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select AN0727 CW989629 (MGI Seq Detail) 5' RACE Chr16:21842499-21850913 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 12 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Senp2 Mutation:	51 strains or lines available

Original:	J:141453 Cheng J, et al., SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007 Nov 2;131(3):584-95
All:	3 reference(s)