Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gsdmdtm1.1Tshir
Name:	gasdermin D; targeted mutation 1.1, Toshihiko Shiroishi
MGI ID:	MGI:3814179
Gene:	Gsdmd  Location: Chr15:75734176-75739257 bp, + strand  Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
Alliance:	Gsdmdtm1.1Tshir page

Germline Transmission:	Earliest citation of germline transmission: J:140319
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Cre-mediated recombination of the Gsdmdtm1Tshir allele removed exons 1 and 2. Gene inactivation was confirmed through northern blotting of total RNA isolated from small intestine. (J:140319)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gsdmd Mutation:	32 strains or lines available

Original:	J:140319 Fujii T, et al., Gasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development. Genesis. 2008 Aug;46(8):418-23
All:	5 reference(s)