Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(GFAP-cre/Esr1*,-lacZ)BSbk
Name:	transgene insertion B, Suzanne J Baker
MGI ID:	MGI:3813947
Synonyms:	GFAP-CreERTM, GFAP-CreERTMB, Tg(GFAP-cre/Esr1)BSbk
Transgene:	Tg(GFAP-cre/Esr1*,-lacZ)BSbk  Location: unknown  Genetic Position: Chr15, Syntenic
Alliance:	Tg(GFAP-cre/Esr1*,-lacZ)BSbk page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(GFAP-cre/Esr1*,-lacZ)BSbk expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human GFAP (2670) Gfap  (MGI:95697)   Mutation details: This transgene consists of a 2.2 kb fragment of the human GFAP promoter, a cDNA encoding a fusion of cre and the ligand binding domain of the human estrogen receptor modified to bind 4-hydroxytamoxifen, but not endogenous estrogen, an IRES, a cDNA encoding beta-galactosidase, and SV40 intronic sequence and polyadenylation signal. Transgene expression, assessed by beta-gal activity, is seen in Bergmann glia, neuronal precursors in the dentate gyrus, and cells in the subventricular zone surrounding the lateral ventricle. When crossed to reporter mice occasional tamoxifen-independent Cre mediated recombination is seen primarily in Bergmann glial cells. (J:140270)

Activity:	Tissue activity of this recombinase allele
Driver:	GFAP (human) Summary of all recombinase alleles driven by GFAP. Comparative matrix view of recombinase activities Alliance human GFAP gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:140270 Chow LM, et al., Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Res. 2008 Oct;17(5):919-28
All:	6 reference(s)