Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Chek2tm1Pjs
Name:	checkpoint kinase 2; targeted mutation 1, Peter J Stambrook
MGI ID:	MGI:3812090
Synonyms:	Chk2*1100delC
Gene:	Chek2  Location: Chr5:110987845-111022011 bp, + strand  Genetic Position: Chr5, 53.73 cM, cytoband F
Alliance:	Chek2tm1Pjs page

Germline Transmission:	Earliest citation of germline transmission: J:118262
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Humanized sequence, Hypomorph, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neo cassette was inserted into intron 12 and exon 13 was replaced with one containing deletion of cytosine at position 1100 (1100delC). This single nucleotide deletion results in a frame shift and premature termination within the kinase domain. (J:118262)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Chek2tm1Pjs

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chek2 Mutation:	53 strains or lines available

Original:	J:118262 Bahassi el M, et al., The breast cancer susceptibility allele CHEK2*1100delC promotes genomic instability in a knock-in mouse model. Mutat Res. 2007 Mar 1;616(1-2):201-9
All:	4 reference(s)