Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adam10tm1Zhu
Name:	a disintegrin and metallopeptidase domain 10; targeted mutation 1, Yuan Zhuang
MGI ID:	MGI:3809598
Synonyms:	Adam10loxP
Gene:	Adam10  Location: Chr9:70586279-70687511 bp, + strand  Genetic Position: Chr9, 39.53 cM
Alliance:	Adam10tm1Zhu page

Germline Transmission:	Earliest citation of germline transmission: J:139042
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 3 was surrounded by loxP sites. Germ line, flp mediated recombination was used to remove the neo selection cassette. (J:139042)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adam10 Mutation:	37 strains or lines available

Original:	J:139042 Tian L, et al., ADAM10 is essential for proteolytic activation of Notch during thymocyte development. Int Immunol. 2008 Sep;20(9):1181-7
All:	17 reference(s)