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Gene Expression Data
Assay Details
Assay
Reference: J:26614 Kessler PM, et al., Expression of the Von Hippel-Lindau tumor suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis. Mol Med. 1995 May;1(4):457-66
Assay type: RNA in situ
MGI Accession ID: MGI:3807494
Gene symbol: Vhl
Gene name: von Hippel-Lindau tumor suppressor
Probe: Vhl cDNA
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen Not shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: embryo Present Expression is present in derivatives of the three germ cell layers.

Specimen 1D: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: heart atrium Present 1D
TS21: heart ventricle Present 1D
TS21: liver Present 1D
TS21: head Present Regionally restricted 1D Expression is present in the branchial arch.
TS21: gonad Present 1D Expression is present in the urogenital ridge.
TS21: central nervous system Present Regionally restricted 1D Expression is present in the cephalad, the adjacent neuroepithelium lining the brain structures.

Specimen 1F: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: liver Present 1F
TS21: pancreas Present 1F Expression is present in developing epithelial structures, as well as stromal.
TS21: metanephros Present 1F

Specimen 1H: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: intestine Moderate 1H
TS21: gonad Present 1H Expression is present in the urogenital ridge and gonad.
TS21: paramesonephric duct Present Regionally restricted 1H Expression is present in the epithelial lining of the mesonephric tubules.

Specimen 1J: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: metanephros Strong 1J
TS21: pancreas Strong 1J
TS21: gland Present Regionally restricted 1J Expression is present in the adrenal gland.
TS21: vertebral cartilage condensation Present 1J
TS21: central nervous system ganglion Present 1J
TS21: female reproductive system Present Regionally restricted 1J Expression is present in the uterus.
TS21: primitive bladder Present 1J
TS21: rectum Present 1J

Specimen Not shown: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cartilage Present
TS21: central nervous system Present
TS21: lung Present
TS21: peripheral nervous system Present
TS21: stomach Present
TS21: thymus primordium Present
TS21: dorsal mesogastrium Present Regionally restricted Expression is present in the spleen.
TS21: skeletal muscle Present Expression is present in somatic muscle.

Specimen 2B: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: heart atrium Present 2B
TS24: heart ventricle Present 2B
TS24: liver Present 2B
TS24: lung Present 2B
TS24: vertebra Present 2B

Specimen 2D: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: adrenal gland Weak 2D
TS24: spleen Weak 2D
TS24: stomach Weak 2D
TS24: metanephros Strong 2D
TS24: testis Strong Non-Uniform 2D Expression is stronger in the seminiferous tubules than in the surrounding stroma.
TS24: appendix epididymis Strong 2D There is strong expression in the epididymis.

Specimen 2F: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: liver Strong Regionally restricted 2F Expression is present within the vascular components.
TS24: pancreas Present 2F Expression is present in developing epithelial structures, as well as stromal.

Specimen 2H: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: ovary Moderate 2H
TS24: uterine horn Moderate 2H

Specimen 3B: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: telencephalon Present 3B , 3D Expression is present in the neuroepithelium.
TS24: nose Present 3B , 3D Expression is present in the nasal process.
TS24: head Moderate Regionally restricted 3B , 3D Expression is present in the branchial arch.
TS24: head mesenchyme Present 3B , 3D Expression is present in cephalic mesenchyme.

Specimen 3F: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebellum Present 3H , 3F Expression levels are higher in these tissues than surrounding tissues.
TS24: medulla oblongata part of 4th ventricle choroid plexus Present 3H , 3F Expression levels are higher in these tissues than surrounding tissues.
TS24: diencephalon Present 3F , 3H Expression is present in the neuroepithlium.
TS24: hindbrain Present 3F , 3H Expression is present in the neuroepithlium.
TS24: midbrain Present 3F , 3H Expression is present in the neuroepithlium.
TS24: thalamus Present 3F , 3H Expression is present in the neuroepithlium.

Specimen 3J: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: midbrain Trace 3J
TS24: pituitary gland Trace 3J
TS24: thalamus Trace 3J

Specimen 3L: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: retina Strong 3L
TS24: lens Present 3L

Specimen 3N: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: retina nuclear layer Strong 3N There is strong expression in the inner and outer neuroblastic layers.
TS24: cornea Present 3N
TS24: lens Present 3N
TS24: vitreous humour Present 3N

Specimen Not shown: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: spinal ganglion Strong
TS24: trigeminal nerve Strong
TS24: vestibulocochlear nerve Strong
TS24: intestine Weak


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory