Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Smad1tm1Tako
Name:	SMAD family member 1; targeted mutation 1, Takashi Kobayashi
MGI ID:	MGI:3805956
Gene:	Smad1  Location: Chr8:80065024-80126057 bp, - strand  Genetic Position: Chr8, 37.56 cM
Alliance:	Smad1tm1Tako page

Germline Transmission:	Earliest citation of germline transmission: J:79513
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The exon encoding part of the MH1 domain and linker region was replaced with a lacZ and neo cassette. The absence of transcript was confirmed by RT-PCR analysis on E7.5 total embryo extracts. (J:79513)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

39 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad1 Mutation:	32 strains or lines available

Original:	J:79513 Hayashi K, et al., SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast. Mech Dev. 2002 Oct;118(1-2):99
All:	4 reference(s)