Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bmi1tm1(cre/ERT)Mrc
Name:	Bmi1 polycomb ring finger oncogene; targeted mutation 1, Mario R Capecchi
MGI ID:	MGI:3805814
Synonyms:	Bmi1CreER, Bmi1tm1(cre/ESR1)Mrc
Gene:	Bmi1  Location: Chr2:18681953-18691440 bp, + strand  Genetic Position: Chr2, 12.9 cM
Alliance:	Bmi1tm1(cre/ERT)Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:138364
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Bmi1tm1(cre/ERT)Mrc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Bmi1 (MGI:88174)   Mutation details: An IRES followed by a cre/ERT fusion and an frt-flanked neo cassette was inserted downstream of the translation stop codon. Germ line, flp-mediated recombination was used to remove the neo cassette. (J:138364)

Activity:	Tissue activity of this recombinase allele
Driver:	Bmi1 (mouse) Summary of all recombinase alleles driven by Bmi1. Comparative matrix view of recombinase activities Alliance mouse Bmi1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bmi1 Mutation:	33 strains or lines available

Original:	J:138364 Sangiorgi E, et al., Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet. 2008 Jul;40(7):915-20
All:	43 reference(s)