Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tk2tm1Anka
Name:	thymidine kinase 2, mitochondrial; targeted mutation 1, Anna Karlsson
MGI ID:	MGI:3802583
Gene:	Tk2  Location: Chr8:104953317-104975190 bp, - strand  Genetic Position: Chr8, 53.04 cM
Alliance:	Tk2tm1Anka page

Germline Transmission:	Earliest citation of germline transmission: J:137664
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exons 4 and 5 were replaced with a neo cassette. (J:137664)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tk2 Mutation:	19 strains or lines available

Original:	J:137664 Zhou X, et al., Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice. Hum Mol Genet. 2008 Aug 1;17(15):2329-35
All:	7 reference(s)