Summary | Transgene origin | Transgene description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(HBB-cre)12Kpe
Name:	transgene insertion 12, Kenneth Peterson
MGI ID:	MGI:3800816
Synonyms:	microLCR-betapr-Cre
Transgene:	Tg(HBB-cre)12Kpe  Location: unknown
Alliance:	Tg(HBB-cre)12Kpe page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(HBB-cre)12Kpe expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human HBB (3043) Hbb-b1  (MGI:96021) Hbb-b2  (MGI:96022) Hbb-bh2  (MGI:96025) Hbb-bs  (MGI:5474852) Hbb-bt  (MGI:5474850)   Mutation details: A transgenic construct containing the sequence encoding Cre recombinase under the control of the human beta hemoglobin (HBB) promoter, intron 2-enhancer fragment, and the human beta hemoglobin locus control region (LCR) was introduced into C57BL/6 donor eggs. Founder line 12 was established. Cre recombinase expression is detected in blood, brain, gonads, spleen and liver by RT-PCR analysis and in blood by RNAse protection assay. Recombination occurs at 50-100% efficiency in erythroid/megakarycytic cell lineages beginning at onset of hematopoiesis at approximately embryonic day 7.5. (J:89725, J:137519)

Activity:	Tissue activity of this recombinase allele
Driver:	HBB (human) Summary of all recombinase alleles driven by HBB. Comparative matrix view of recombinase activities Alliance human HBB gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:137519 Peterson KR, Generation of an erythroid-specific cre transgenic mouse. MGI Direct Data Submission. 2008;
All:	4 reference(s)