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Nedd4Gt(XB786)Byg
Gene trapped Allele Detail
Summary
Symbol: Nedd4Gt(XB786)Byg
Name: neural precursor cell expressed, developmentally down-regulated 4; gene trap XB786, BayGenomics
MGI ID: MGI:3799317
Synonyms: Nedd4-1-trap
Gene: Nedd4  Location: Chr9:72569628-72657134 bp, + strand  Genetic Position: Chr9, 40.08 cM
Alliance: Nedd4Gt(XB786)Byg page
Mutation
origin
Mutant Cell Line:  XB786
Germline Transmission:  Earliest citation of germline transmission: J:137202
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0pfs     Vector Type: gene trap
 
Mutation details: The gene trap vector, containing the lacZ gene, was inserted between exons 6 and 7. The absence of protein product was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:137202)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nedd4 Mutation:  116 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:137202 Fouladkou F, et al., The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8585-90
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory