Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(PSCA-EGFP)1Witt
Name:	transgene insertion 1, Owen N Witte
MGI ID:	MGI:3798848
Synonyms:	PSCA-GFP
Transgene:	Tg(PSCA-EGFP)1Witt  Location: unknown
Alliance:	Tg(PSCA-EGFP)1Witt page

Strain of Origin:

(C57BL/6 x C3H)F1

Transgene Type:    Transgenic (Reporter) Mutation:    Insertion   Mutation details: A transgenic vector carrying 9 kb of the 5' flanking sequence and 5 bp of the untranslated region of human prostate stell cell antigen driving expression of enhanced green fluorescent protein (EGFP) was introduced into (C57BL/6 x C3H)F1 embryos. Expression is detected in mid-gestation following the appearance of prostatic buds from the urogenital sinus. In adult mice, EGFP expression is restricted to a subset of cells located in the distal tips of the prostate gland towards the urethra. GFP expression increases during puberty and regeneration driven by androgen which are associated with expansive growth of the prostate. Transient GFP expression was detected in the most superficial epidermal skin layer embryonically, but was extinguished with age. No other organs or tissues exhibited detectable transgenic protein expression. (J:73560)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:73560 Watabe T, et al., Growth, regeneration, and tumorigenesis of the prostate activates the PSCA promoter. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):401-6
All:	1 reference(s)