Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Kdm5atm1Kael
Name:	lysine demethylase 5A; targeted mutation 1, William G Kaelin
MGI ID:	MGI:3798767
Gene:	Kdm5a  Location: Chr6:120341085-120421535 bp, + strand  Genetic Position: Chr6, 56.95 cM
Alliance:	Kdm5atm1Kael page

Germline Transmission:	Earliest citation of germline transmission: J:137185
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was generated by flanking exons 5 and 6 with a 5' loxP site and a 3' Frt-PGK-neomycin-Frt-LoxP expression cassette. Germline transmitting mice were bred with CAGG-Flpe transgenic mice to generate the floxed allele. (J:137185)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Kdm5atm1Kael

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kdm5a Mutation:	76 strains or lines available

Original:	J:137185 Klose RJ, et al., The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell. 2007 Mar 9;128(5):889-900
All:	5 reference(s)