Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vamp2tm1(cre/ERT)Nat
Name:	vesicle-associated membrane protein 2; targeted mutation 1, Jeremy Nathans
MGI ID:	MGI:3795865
Synonyms:	VAMP2-IRES-creER, Vamp2tm1(cre/Esr1)Nat
Gene:	Vamp2  Location: Chr11:68979354-68983207 bp, + strand  Genetic Position: Chr11, 42.36 cM
Alliance:	Vamp2tm1(cre/ERT)Nat page

Germline Transmission:	Earliest citation of germline transmission: J:144315
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Vamp2tm1(cre/ERT)Nat expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Vamp2 (MGI:1313277)   Mutation details: An IRES-creER cassette, a tetracycline resistance gene and a Frt-flanked neomycin selection marker were all knocked in to the 3' UTR of the gene. The neomycin selection marker was removed by crossing to a C57BL/6 background Flp recombinase strain. Flp was then bred out of the line. When crossed with a Tg(CAG-Bgeo/ALPP)1Lbe reporter strain and given tamoxifen, cre expression was detected in a wide variety of neural and glial cells of the brain. This is line B4. (J:144315)

Activity:	Tissue activity of this recombinase allele
Driver:	Vamp2 (mouse) Summary of all recombinase alleles driven by Vamp2. Comparative matrix view of recombinase activities Alliance mouse Vamp2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vamp2 Mutation:	18 strains or lines available

Original:	J:144315 Rotolo T, et al., Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology. PLoS One. 2008;3(12):e4099
All:	2 reference(s)