Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pik3cbtm1Bvan
Name:	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1, Bart Vanhaesebroeck
MGI ID:	MGI:3795849
Synonyms:	p110betaflox
Gene:	Pik3cb  Location: Chr9:98920455-99022264 bp, - strand  Genetic Position: Chr9, 51.41 cM, cytoband E4
Alliance:	Pik3cbtm1Bvan page

Germline Transmission:	Earliest citation of germline transmission: J:136305
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 21 and an frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 22. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 21 and 22 floxed. (J:136305)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3cb Mutation:	151 strains or lines available

Original:	J:136305 Guillermet-Guibert J, et al., The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7
All:	15 reference(s)