Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(GPD1)3Bir
Name:	transgene insertion 3, Edward H Birkenmeier
MGI ID:	MGI:3795203
Synonyms:	GPDH-B
Transgene:	Tg(GPD1)3Bir  Location: unknown
Alliance:	Tg(GPD1)3Bir page

Strain of Origin:

(C57BL/6J x SJL/J)F2

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(GPD1)3Bir expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human GPD1 (2819) Gpd1  (MGI:95679)   Mutation details: The transgene comprises 12.3 kb of human genomic DNA containing the GPD1 gene, consisting of 3.5 kb of 5' flanking sequence, the 7.6 kb protein-coding region and 1.2 kb of 3' flanking DNA. The 5' flanking sequence includes the proximal and distal promoter regions. Founder line 3 (GPDH-B) has approximately 4 copies of the transgene. The transgene is expressed at higher levels in the cerebral cortex and kidney than the endogenous gene. (J:135002)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:135002 Birkenmeier EH, et al., Tissue- and cell-specific expression of human sn-glycerol-3-phosphate dehydrogenase in transgenic mice. Nucleic Acids Res. 1992 Jun 11;20(11):2819-25
All:	1 reference(s)