Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ace2tm1Hira
Name:	angiotensin converting enzyme 2; targeted mutation 1, Hiromi Rakugi
MGI ID:	MGI:3794966
Gene:	Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Alliance:	Ace2tm1Hira page

Germline Transmission:	Earliest citation of germline transmission: J:135766
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was replaced with a neo cassette. The absence of protein product was confirmed by westen blot analysis. (J:135766)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:	54 strains or lines available

Original:	J:135766 Yamamoto K, et al., Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension. 2006 Apr;47(4):718-26
All:	12 reference(s)