Tg(Tec-BCR/ABL1)#Hhi
Transgene Detail
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| Symbol: |
Tg(Tec-BCR/ABL1)#Hhi |
| Name: |
transgene insertion, Hisamaru Hirai |
| MGI ID: |
MGI:3527269 |
| Synonyms: |
p210BCR/ABL |
| Transgene: |
Tg(Tec-BCR/ABL1)#Hhi Location: unknown
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| Alliance: |
Tg(Tec-BCR/ABL1)#Hhi page
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| Strain of Origin: |
C57BL/6 and DBA/2
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Tec-BCR/ABL1)#Hhi expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
ABL1 (25) |
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Transgene codes for a fusion protein of human BCR and ABL1. |
| human |
BCR (613) |
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Transgene codes for a fusion protein of human BCR and ABL1. |
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Tg(Tec-BCR/ABL1)#Hhi expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Tec (MGI:98662) |
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Mutation details: Fusion gene of human BCR and ABL1 encoding an oncogenic 210 kDa protein (p210BCR/ABL). Expression of the cDNA is controlled by the mouse Tec promoter.
(J:46392)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:46392 Honda H, et al., Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias. Blood. 1998 Mar 15;91(6):2067-75 |
| All: |
8 reference(s) |
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Analysis Tools
