Tg(MMTV-Erbb2*)YB2Mul
Transgene Detail
|
|
| Symbol: |
Tg(MMTV-Erbb2*)YB2Mul |
| Name: |
transgene insertion YB2, William J Muller |
| MGI ID: |
MGI:3794034 |
| Transgene: |
Tg(MMTV-Erbb2*)YB2Mul Location: unknown
|
| Alliance: |
Tg(MMTV-Erbb2*)YB2Mul page
|
|
|
|
| Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
| Mutation: |
|
Insertion
|
| |
|
Tg(MMTV-Erbb2*)YB2Mul expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| rat |
Erbb2 (24337) |
|
|
|
| |
|
Mutation details: A rat Erbb2 cDNA containing an activating mutation and point mutations in the catalytic domain is expressed under the control of the MMTV LTR with SV40 polyadenylation and splicing signals. The activating mutation, derived from a clone isolated from mouse mammary tumor tissue, consists of a 12 codon in-frame deletion (neu8142 or NDL1) in the region encoding the extracellular region directly adjacent to the transmembrane domain. In addition, sequences encoding the tyrosine kinase domain were altered to mutate residues 1028 (site A), 1201 (site C), 1226/1227 (site D), and 1253 (site E) from tyrosine to phenylalanine. An additional tyrosine residue at 1144 (site B) was not mutated. Expression of the transgene in mammary tissue was confirmed by RT-PCR.
(J:67363)
|
|
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:67363 Dankort D, et al., Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer. Mol Cell Biol. 2001 Mar;21(5):1540-51 |
| All: |
3 reference(s) |
|
Analysis Tools
