Tg(MMTV-Erbb2*)NDL1-4Mul
Transgene Detail
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| Symbol: |
Tg(MMTV-Erbb2*)NDL1-4Mul |
| Name: |
transgene insertion NDL1-4, William J Muller |
| MGI ID: |
MGI:3793947 |
| Synonyms: |
NDL1-4 |
| Transgene: |
Tg(MMTV-Erbb2*)NDL1-4Mul Location: unknown
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| Alliance: |
Tg(MMTV-Erbb2*)NDL1-4Mul page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(MMTV-Erbb2*)NDL1-4Mul expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| rat |
Erbb2 (24337) |
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Mutation details: A rat Erbb2 cDNA containing an activating mutation is expressed under the control of the MMTV LTR with SV40 polyadenylation and splicing signals. The activating mutation, derived from a clone isolated from mouse mammary tumor tissue, consists of a 12 codon in-frame deletion (neu8142) in the region encoding the extracellular region directly adjacent to the transmembrane domain. The major sites of expression of the transgene in female carriers include the mammary and salivary glands with lower levels detectable in lungs and ovaries. In male carriers, transgene expression is detectable in salivary gland and reproductive organs, with variable expression in mammary gland and lungs.
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:54661 Siegel PM, et al., Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer. EMBO J. 1999 Apr 15;18(8):2149-64 |
| All: |
1 reference(s) |
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Analysis Tools
