Tg(MMTV-Akt1*T308D*S473D)7Mul
Transgene Detail
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| Symbol: |
Tg(MMTV-Akt1*T308D*S473D)7Mul |
| Name: |
transgene insertion 7, William J Muller |
| MGI ID: |
MGI:3794053 |
| Synonyms: |
Akt7, MMTV-Akt1-DD, MMTV/AktDD-7 |
| Transgene: |
Tg(MMTV-Akt1*T308D*S473D)7Mul Location: unknown
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| Alliance: |
Tg(MMTV-Akt1*T308D*S473D)7Mul page
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| Transgene Type: |
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Transgenic (Constitutively active, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: This transgene contains a constitutively active mouse Akt1, in which critical residues (T308D/S473D) for activation of Akt1 are replaced by negatively charged amino acids, under the control of the mouse mammary tumor virus LTR. Mammary glands express significant levels of the transgene.
(J:68521)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:68521 Hutchinson J, et al., Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol. 2001 Mar;21(6):2203-12 |
| All: |
3 reference(s) |
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Analysis Tools
