Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(H2-Aa)26Dim
Name:	transgene insertion 26, Diane Mathis
MGI ID:	MGI:3793688
Synonyms:	Aa26
Transgene:	Tg(H2-Aa)26Dim  Location: unknown
Alliance:	Tg(H2-Aa)26Dim page

Strain of Origin:

(C57BL/6 x SJL)F2

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(H2-Aa)26Dim expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse H2-Aa (MGI:95895)   Mutation details: A transgenic construct containing the entire mouse (AKR/J strain) H2-Aa kappa genomic DNA sequence was microinjected into (C57BL/6 x SJL)F2 embryos. Two lines Aalpha10 and Aalpha26 were generated. Line 26 was crossed to mice carrying Tg(H2-Ab1)62Dim and the resulting double transgenic line was donated to The Jackson Laboratory. The construct was also injected into C57BL/6 embryos to have the transgene on a homogeneous genetic background. Line 46 was established (Aalpha46). S1-mapping shows normal patterns of high expression in spleen, lung and thymus. (J:110897)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:110897 Fehling HJ, et al., Functional consequences of overexpressed Ia antigens in AK alpha/AK beta transgenic mice. J Immunol. 1990 Apr 15;144(8):2865-74
All:	2 reference(s)