Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gria1tm5Rlh
Name:	glutamate receptor, ionotropic, AMPA1 (alpha 1); targeted mutation 5, Richard L Huganir
MGI ID:	MGI:3793349
Synonyms:	Gria1Ser 831
Gene:	Gria1  Location: Chr11:56902342-57221070 bp, + strand  Genetic Position: Chr11, 34.51 cM
Alliance:	Gria1tm5Rlh page

Germline Transmission:	Earliest citation of germline transmission: J:135196
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Applicable) Mutation:    Insertion   Mutation details: Exon 17 was replaced with one in which a nucleotide substitution resulted in an amio acid substitution of alanine for serine at position 831 (S831A). A neo cassette used as a selectable marker was removed by germline, cre-mediated recombination. (J:135196)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gria1 Mutation:	62 strains or lines available

Original:	J:135196 Crombag HS, et al., A necessary role for GluR1 serine 831 phosphorylation in appetitive incentive learning. Behav Brain Res. 2008 Aug 22;191(2):178-83
All:	7 reference(s)