Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(Thy1-SOD1*G93A)T3Hgrd
Name:	transgene insertion T3, Casper Hoogenraad
MGI ID:	MGI:3785090
Synonyms:	Thy1.2-G93A
Transgene:	Tg(Thy1-SOD1*G93A)T3Hgrd  Location: unknown
Alliance:	Tg(Thy1-SOD1*G93A)T3Hgrd page

Strain of Origin:

FVB

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Thy1-SOD1*G93A)T3Hgrd expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human SOD1 (6647) Sod1  (MGI:98351)   Mutation details: The transgene construct contains a modified regulatory region of the murine thy1.2 gene (extending from the promoter to the intron following exon 4, excluding exon 3 and its flanking introns), upstream of a mutant human superoxide dismutase cDNA sequence (G93A-SOD1) harboring a single amino acid substitution of glycine to alanine at codon 93. Transgene expression throughout the brain and spinal cord was determined by western blot. Line T3 was characterized further. (J:134095)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:134095 Jaarsma D, et al., Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice. J Neurosci. 2008 Feb 27;28(9):2075-88
All:	2 reference(s)