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Nupr1tm1Jlio
Targeted Allele Detail
Summary
Symbol: Nupr1tm1Jlio
Name: nuclear protein transcription regulator 1; targeted mutation 1, Juan Lucio Iovanna
MGI ID: MGI:3784016
Synonyms: p8-
Gene: Nupr1  Location: Chr7:126222418-126224642 bp, - strand  Genetic Position: Chr7, 69.21 cM, cytoband F4
Alliance: Nupr1tm1Jlio page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133728
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 is replaced by a neomycin cassette in reverse orientation. Loss of protein product in the pancreas was confirmed by Western blot analysis. (J:133728)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nupr1 Mutation:  8 strains or lines available
References
Original:  J:133728 Vasseur S, et al., p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis. Oncogene. 2002 Mar 7;21(11):1685-94
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory