Tg(Epo-DTA)#Nal
Transgene Detail
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| Symbol: |
Tg(Epo-DTA)#Nal |
| Name: |
transgene insertion, Nancy A Lee |
| MGI ID: |
MGI:3779020 |
| Synonyms: |
PHIL, Tg(Epx-DTA)#Nal |
| Transgene: |
Tg(Epo-DTA)#Nal Location: unknown
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| Alliance: |
Tg(Epo-DTA)#Nal page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: Transgenic mice were created that contain a DNA fragment containing 3717 bp of sequence upstream from the transcription start site of the mouse Epx gene (formerly EPO) as well as the first 54 bp encoding the 5'-untranslated region of the Epx mRNA followed by the open reading frame encoding the Diphtheria Toxin A chain. The DTA expression construct was completed with the addition of a series of exons-introns derived from a 2.1kb fragment encoding a truncated portion of the human growth hormone gene downstream of the DTA open reading frame. Analysis of circulating leukocytes demonstrated that transgenic animals were devoid of eosinophils but otherwise have a full complement of hematopoietically derived cells.
(J:92831)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:92831 Lee JJ, et al., Defining a link with asthma in mice congenitally deficient in eosinophils. Science. 2004 Sep 17;305(5691):1773-6 |
| All: |
34 reference(s) |
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Analysis Tools
