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Gene Expression Data
Assay Details
Assay
Reference: J:15715 Monaghan AP, et al., Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development. 1993 Nov;119(3):567-78
Assay type: RNA in situ
MGI Accession ID: MGI:3778014
Gene symbol: Foxa2
Gene name: forkhead box A2
Probe: HNF3b cDNA
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen Not shown: embryonic day 6.5 (more )
Structure Level Pattern Image Note
TS9: embryo ectoderm Present Regionally restricted Expression is present in a few cells in the lateral part of the egg cylinder at the site of primitive streak formation in both the ectoderm and primitive endoderm cell layers.
TS9: primitive endoderm Present Regionally restricted Expression is present in a few cells in the lateral part of the egg cylinder at the site of primitive streak formation in both the ectoderm and primitive endoderm cell layers.

Specimen 2B: embryonic day 7.5 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS11: node Present 2B
TS11: embryo ectoderm Present Regionally restricted 2B Expression is localized to the anterior tip of the primitive streak in all three germ layers.
TS11: embryo endoderm Present Regionally restricted 2B Expression is localized to the anterior tip of the primitive streak in all three germ layers.
TS11: embryo mesoderm Present Regionally restricted 2B Expression is localized to the anterior tip of the primitive streak in all three germ layers.
TS11: neural ectoderm Present Regionally restricted 2B Expression is localised to cells in the midline adjacent to the endoderm and prechordal plate.

Specimen 2C: embryonic day 7.5 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS11: embryo Present Graded 2C Expressing cells show a gradient of expression decreasing from the archenteron to the head fold. There is no expression in any germ layer stretching posterior to the archenteron.
TS11: definitive endoderm Present 2C Expression is present in all axial endoderm cells stretching anteriorly from and including the node.
TS11: notochordal process Present 2C
TS11: embryo ectoderm Present 2C

Specimen 2E: embryonic day 8.0 (more )
Structure Level Pattern Image Note
TS12: foregut diverticulum endoderm Strong 2E Expression is present throughout the anterior foregut endoderm.
TS12: neural ectoderm Present Regionally restricted 2E There is a strict anterior boundary of expression in the neuroepithelium and notochord.
TS12: notochord Present Regionally restricted 2E There is a strict anterior boundary of expression in the neuroepithelium and notochord.

Specimen 2F: embryonic day 8.75-9.0 (more )
Structure Level Pattern Image Note
TS14: gut epithelium Present Regionally restricted 2F Expression is present in the endoderm of the foregut and hindgut pocket.
TS14: notochord Absent 2F

Specimen 3B: embryonic day 9.0 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS14: embryo endoderm Present 3B Expression is observed in all endoderm-derived structures extending from the stomadaeum posterior.
TS14: floor plate Present 3B
TS14: future diencephalon Present 3B

Specimen Not shown: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: septum transversum Strong Regionally restricted Expression is present in the ventral floor of the foregut at the site of the primary hepatic diverticulum.

Specimen 3E: embryonic day 10.0 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS16: embryo endoderm Present 3E
TS16: central nervous system Present 3E Expression is present in the neuroepithelium.
TS16: floor plate Present 3E
TS16: liver Present 3E
TS16: lung epithelium Present 3E
TS16: foregut Present Regionally restricted 3E Expression is present in the stomach.
TS16: Rathke's pouch Absent 3E

Specimen 4B: embryonic day 11.5 (more )
Note: This is a sagittal section.
Structure Level Pattern Image Note
TS19: floor plate Present 4B
TS19: tongue Strong Regionally restricted 4B Expression is present in the epithelium.
TS19: embryo mesenchyme Absent 4B
TS19: liver Present 4B Expression in the liver is decreasing.

Specimen 4D: embryonic day 13.5 (more )
Note: This is a sagittal section of the intestinal tract.
Structure Level Pattern Image Note
TS21: tongue Absent 4D
TS21: esophagus Present 4D

Specimen 4E: embryonic day 13.5 (more )
Note: This is a sagittal section of the intestinal tract.
Structure Level Pattern Image Note
TS21: floor plate Present 4E
TS21: lung Present 4E
TS21: stomach Present 4E
TS21: liver Weak Regionally restricted 4E The liver is very weakly positive with nonexpressing regions.

Specimen Not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: lung epithelium Present

Specimen Not shown: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: esophagus Absent
TS22: trachea Absent

Specimen Not shown: embryonic day 11.5-12.5 (more )
Structure Level Pattern Image Note
TS20: gallbladder Present
TS20: dorsal mesogastrium Present Regionally restricted Expression is present in the developing spleen.

Specimen Not shown: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: skeleton Absent There is no expression in developing bone tissue.

Specimen 5B: embryonic day 12.5 (more )
Note: This is a transverse section.
Structure Level Pattern Image Note
TS20: floor plate Present 5B Expression is localized to the developing floor plate cells as soon as the floor plate becomes morphologically distinct.
TS20: esophagus Present 5B
TS20: trachea Present 5B
TS20: notochord Absent 5B
TS20: embryo mesenchyme Absent 5B There is no expression in the mesenchyme surrounding the notochord.

Specimen Not shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: intestine Absent
TS22: stomach Absent

Specimen 6B: embryonic day 7.75 (more )
Note: This is a transverse section.
Structure Level Pattern Image Note
TS11: neural fold Present Regionally restricted 6B Expression is present in the base of the neural fold, in the cells that will give rise to the floor plate.
TS11: embryo endoderm Present 6B

Specimen 6D: embryonic day 12.5 (more )
Note: This is a transverse section through the brain.
Structure Level Pattern Image Note
TS20: diencephalon lateral wall ventricular layer Present 6D
TS20: hypothalamus Present 6D
TS20: midbrain ventricular layer Present 6D
TS20: spinal cord floor plate Present 6D
TS20: thalamus Present Regionally restricted 6D Expression is present in the ventral thalamus, with an anterior border located in the ventral/dorsal thalamic boundary region.

Specimen Not shown: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: hindbrain Present Regionally restricted Expression is present in cells in the ventricular zone of the fourth ventricle.
TS23: pons Present Regionally restricted Expression is present in the ventral tegmental nucleus.
TS23: midbrain tegmentum Present Regionally restricted Expression is present in the red nucleus.
TS23: thalamus Present Regionally restricted Expression is present in the dorsal thalamic regions.

Specimen Table 1: embryonic day 6.5 (more )
Structure Level Pattern Image Note
TS9: embryo ectoderm Present
TS9: embryo endoderm Present

Specimen Table 1: embryonic day 7.5 (more )
Structure Level Pattern Image Note
TS11: embryo ectoderm Present
TS11: embryo endoderm Present
TS11: embryo mesoderm Present
TS11: neural fold Present
TS11: notochordal process Present

Specimen Table 1: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: embryo ectoderm Present
TS13: embryo endoderm Present
TS13: embryo mesenchyme Present
TS13: foregut diverticulum Present
TS13: future prosencephalon Present
TS13: hindgut diverticulum Present
TS13: neural fold Present
TS13: neural plate Present
TS13: notochord Present
TS13: stomatodeum Present

Specimen Table 1: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: embryo endoderm Present
TS15: floor plate Present
TS15: future forebrain Present
TS15: hindgut Present
TS15: lung Present
TS15: midgut Present
TS15: pharynx Present
TS15: oral region Present Expression is present in the stomodaeum.
TS15: foregut Present Expression is present in the foregut, including the stomach.
TS15: hepatic primordium Present
TS15: pancreas primordium Present

Specimen Table 1: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: esophagus Present
TS17: floor plate Present
TS17: forebrain Present
TS17: foregut Present
TS17: hindgut Present
TS17: liver Present
TS17: lung Present
TS17: midgut Present
TS17: pharynx Present
TS17: stomach Present
TS17: thyroid primordium Present
TS17: pancreas primordium Present
TS17: gland Present Regionally restricted Expression is present in the adrenal.

Specimen Table 1: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: esophagus Present
TS19: floor plate Present
TS19: forebrain Present
TS19: foregut Present
TS19: hindgut Present
TS19: liver Present
TS19: lung Present
TS19: midgut Present
TS19: pancreas primordium Present
TS19: pharynx Present
TS19: stomach Present
TS19: thyroid gland Present
TS19: tongue Present
TS19: oral region gland Present Regionally restricted Expression is present in the submandibular gland.
TS19: gland Present Regionally restricted Expression is present in the adrenal.

Specimen Table 1: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: esophagus Present
TS20: floor plate Present
TS20: forebrain Present
TS20: foregut Present
TS20: hindgut Present
TS20: liver Present
TS20: lung Present
TS20: midgut Present
TS20: pancreas Present
TS20: pharynx Present
TS20: stomach Present
TS20: thyroid gland Present
TS20: tongue Present
TS20: oral region gland Present Regionally restricted Expression is present in the submandibular gland.
TS20: gland Present Regionally restricted Expression is present in the adrenal.

Specimen Table 1: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: esophagus Present
TS21: floor plate Present
TS21: forebrain Present
TS21: lung Present
TS21: pancreas Present
TS21: thyroid gland Present
TS21: vertebral cartilage condensation Present
TS21: gland Present Regionally restricted Expression is present in the adrenal.

Specimen Table 1: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: adrenal gland Present
TS22: floor plate Present
TS22: forebrain Present
TS22: lung Present
TS22: vertebral cartilage condensation Present

Specimen Table 1: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: hindgut Present
TS23: liver Present
TS23: lung Present
TS23: midgut Present
TS23: stomach Present

Specimen Table 1: postnatal adult (more )
Structure Level Pattern Image Note
TS28: gut Present Regionally restricted Expression is present in the midgut and hindgut.
TS28: liver Present
TS28: lung Present
TS28: stomach Present


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory