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Tg(CD2-Tbx21)732Staka
Transgene Detail
Summary
Symbol: Tg(CD2-Tbx21)732Staka
Name: transgene insertion 732, Satoru Takahashi
MGI ID: MGI:3777812
Synonyms: T-bet-tg, VA T-bet line732
Transgene: Tg(CD2-Tbx21)732Staka  Location: unknown  
Alliance: Tg(CD2-Tbx21)732Staka page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CD2-Tbx21)732Staka expresses 1 gene
 
Mutation details: A full-length, 2.5-kb mouse Tbx21 cDNA was inserted into the VA CD2 expression vector between, 5', the promoter, ATG-free mutant first exon and first intron of the human CD2 gene and 3', also from the CD2 gene, ~500 bp of 3' untranslated and flanking DNA including two polyadenylation signals and the 3' locus control region. A lacZ reporter gene was shown to be expressed from this vector in mature peripheral CD4+CD8- and CD4-CD8+ SP T lymphocytes and in peripheral CD4-CD8- DN T cells. (J:105228, J:128630)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
This particular transgenic line is not specifically described in the literature. Ishizaki et al. (J:133041) report generation of Tg lines 725 and 731 and crossing them to C57BL/6 for 4 generations. Kiwamoto et al. (J:128630) do not identify the transgenic lines used and says they were backcrossed to BALB/c for 8 generations.
References
Original:  J:128630 Kiwamoto T, et al., Transcription factors T-bet and GATA-3 regulate development of airway remodeling. Am J Respir Crit Care Med. 2006 Jul 15;174(2):142-51
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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