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Tg(CD2-Gata3)1Staka
Transgene Detail
Summary
Symbol: Tg(CD2-Gata3)1Staka
Name: transgene insertion 1, Satoru Takahashi
MGI ID: MGI:3777641
Synonyms: GATA-3-tg, VA-GATA-3/1 Tg
Transgene: Tg(CD2-Gata3)1Staka  Location: unknown  
Alliance: Tg(CD2-Gata3)1Staka page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CD2-Gata3)1Staka expresses 1 gene
 
Mutation details: A a full-length, 2-kb mouse Gata3 cDNA was inserted into the VA CD2 expression vector between, 5', the promoter, ATG-free mutant first exon and first intron of the human CD2 gene and 3', also from the CD2 gene, ~500 bp of 3' untranslated and flanking DNA including two polyadenylation signals and the 3' locus control region. A lacZ reporter gene was shown to be expressed from this vector in mature peripheral CD4+CD8- and CD4-CD8+ SP T lymphocytes and in peripheral CD4-CD8- DN T cells. (J:105228, J:131473)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
This record is representative of at least two transgenic lines. Yoh et al. (J:131473) describe crossing mice of two transgenic lines (Tg 379, estimated by densitometric analysis to contain a single copy of the transgene; and Tg 720, with ~7 copies) to C57BL/6 for 3 generations, then to BXSB/MpJ-Yaa. Kiwamoto et al. (J:128630) say congenic mice were crossed to BALB/c for 8 generations; it is not stated whether they were of line Tg 379 and/or Tg 720.
References
Original:  J:131473 Yoh K, et al., Transgenic overexpression of GATA-3 in T lymphocytes improves autoimmune glomerulonephritis in mice with a BXSB/MpJ-Yaa genetic background. J Am Soc Nephrol. 2003 Oct;14(10):2494-502
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory