Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Rap1btm1Morz
Name:	RAS related protein 1b; targeted mutation 1, Alexei Morozov
MGI ID:	MGI:3777593
Synonyms:	Rap1Bfloxed
Gene:	Rap1b  Location: Chr10:117650502-117681879 bp, - strand  Genetic Position: Chr10, 66.32 cM, cytoband D2
Alliance:	Rap1btm1Morz page

Germline Transmission:	Earliest citation of germline transmission: J:132855
Parent Cell Line:	MM13 (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP-flanked neomycin selection cassette was inserted upstream of exon 1 with an additional loxP site inserted downstream of the exon. Transient expression of cre recombinase removed the neomycin selection cassette leaving exon 1 flanked by loxP sites. Correct targeted was confirmed through Southern blotting. (J:132855)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

123 assay results

List all tumor models in MMHCdb carrying Rap1btm1Morz

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rap1b Mutation:	32 strains or lines available

Original:	J:132855 Pan BX, et al., Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. J Neurosci. 2008 Feb 27;28(9):2089-98
All:	29 reference(s)