Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Rap1atm1Morz
Name:	RAS-related protein 1a; targeted mutation 1, Alexei Morozov
MGI ID:	MGI:3777591
Synonyms:	Rap1Afloxed
Gene:	Rap1a  Location: Chr3:105634583-105708652 bp, - strand  Genetic Position: Chr3, 46.45 cM
Alliance:	Rap1atm1Morz page

Germline Transmission:	Earliest citation of germline transmission: J:132855
Parent Cell Line:	MM13 (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2 and a loxP-flanked neomycin selection cassette was inserted downstream of exon 3. Transient expression of cre recombinase removed the neomycin cassette, leaving exons 2 and 3 flanked by loxP sites. Correct targeting was confirmed through Southern blots. (J:132855)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

123 assay results

List all tumor models in MMHCdb carrying Rap1atm1Morz

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rap1a Mutation:	23 strains or lines available

Original:	J:132855 Pan BX, et al., Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. J Neurosci. 2008 Feb 27;28(9):2089-98
All:	28 reference(s)