Gene Expression Data
Assay Details
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Assay
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Reference:
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J:132026
Farrington-Rock C, et al., Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome. Hum Mol Genet. 2008 Mar 1;17(5):631-41
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Assay type:
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In situ reporter (knock in)
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MGI Accession ID:
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MGI:3776107
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Gene symbol:
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Flnb
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Gene name:
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filamin, beta
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Reporter:
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lacZ
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Direct Detection
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Assay notes:
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Embryos were fixed in neutral-buffered formalin.
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Results
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Specimen
Not shown:
(close  )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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FlnbGt(RRF239)Byg/Flnb+
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Age:
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embryonic day 10.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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Not Specified
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Fixation:
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Formalin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS17: forelimb bud |
Present |
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| TS17: head |
Present |
Regionally restricted |
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Expression is present in the frontal and hind regions of the developing calvarium.
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| TS17: heart |
Present |
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Specimen
4A:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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FlnbGt(RRF239)Byg/Flnb+
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Age:
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embryonic day 12.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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whole mount
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Fixation:
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Formalin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: skeleton |
Present |
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4A
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Expression is localized to the developing skeletal elements.
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Specimen
4C:
embryonic day 12.5; FlnbGt(RRF239)Byg/Flnb +
(more  )
Note: Transverse section through the upper thorax and forelimb.
Specimen
4C:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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FlnbGt(RRF239)Byg/Flnb+
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Age:
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embryonic day 12.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Formalin
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Note:
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Transverse section through the upper thorax and forelimb.
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Specimen
4D:
embryonic day 12.5; FlnbGt(RRF239)Byg/Flnb +
(more )
Note: Transverse section through the trunk.
Specimen
4D:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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FlnbGt(RRF239)Byg/Flnb+
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Age:
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embryonic day 12.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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section
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Fixation:
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Formalin
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Note:
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Transverse section through the trunk.
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Specimen
Not shown:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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FlnbGt(RRF239)Byg/Flnb+
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Age:
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embryonic day 12.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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Not Specified
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Fixation:
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Formalin
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: cranium |
Present |
Regionally restricted |
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Expression is present in the skull bones.
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Specimen
Not shown:
(close )
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Genetic Background:
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involves: 129P2/OlaHsd * C57BL/6
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Mutant Allele(s):
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FlnbGt(RRF239)Byg/Flnb+
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Age:
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embryonic day 14.5
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Age Note:
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Age of embryo at noon of plug day not specified in reference.
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Sex:
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Not Specified
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Type:
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Not Specified
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Fixation:
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Formalin
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