Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Nrastm1Tyj
Name:	neuroblastoma ras oncogene; targeted mutation 1, Tyler Jacks
MGI ID:	MGI:3775824
Synonyms:	NrasG12D, NrasLoxp-STOP-Loxp (LSL) G12D, NrasLSL-G12D
Gene:	Nras  Location: Chr3:102965643-102975230 bp, + strand  Genetic Position: Chr3, 45.25 cM
Alliance:	Nrastm1Tyj page

Germline Transmission:	Earliest citation of germline transmission: J:132357
Parent Cell Line:	V26.2 (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A loxP site, a puromycin resistance gene cassette and a STOP cassette, and a second loxP site were inserted into intron 1 and a p.G12D activating mutation was introduced in exon 2. The allele will only be expressed after Cre-mediated deletion of the STOP cassette. (J:132357)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nras Mutation:	44 strains or lines available

Original:	J:132357 Haigis KM, et al., Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet. 2008 Mar 30;40(5):600-8
All:	42 reference(s)