Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Fkbp8Gt(OST287985)Lex
Name:	FK506 binding protein 8; gene trap OST287985, Lexicon Genetics
MGI ID:	MGI:3775614
Synonyms:	Fkbp8Gt(neo)
Gene:	Fkbp8  Location: Chr8:70980374-70987978 bp, + strand  Genetic Position: Chr8, 34.15 cM, cytoband C1
Alliance:	Fkbp8Gt(OST287985)Lex page

Mutant Cell Line:	OST287985
Germline Transmission:	Earliest citation of germline transmission: J:132031
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Gene trapped (Modified isoform(s), Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: A Lexicon gene trap vector was inserted into the first intron at nucleotide position 1085, which is 666 bp upstream of the ATG. The gene trap was integrated between the transcriptional start sites of two of the three alternative first exons, 1b and 1c. RT-PCR confirmed presence of 1a- and 1b-NEO transcripts and absence of wild-type 1a and 1b transcripts in homozygous E9.5 embryos. Although 1c-WT transcript was not trapped by the insertion, it was barely detectable in the homozygous. In situ hybridization and the western blot confirmed absence of all three full length transcripts and mature proteins. (J:132031) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select OST287985 CG608150 (MGI Seq Detail) 3' RACE Chr8:70982038-70983884 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 26 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	47 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fkbp8 Mutation:	22 strains or lines available

Original:	J:132031 Wong RL, et al., Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Hum Mol Genet. 2008 Feb 15;17(4):587-601
All:	4 reference(s)