Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Syt11tm1Sud
Name:	synaptotagmin XI; targeted mutation 1, Thomas C Sudhof
MGI ID:	MGI:3774591
Gene:	Syt11  Location: Chr3:88652006-88682466 bp, - strand  Genetic Position: Chr3, 38.96 cM
Alliance:	Syt11tm1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:131804
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to place a LoxP-Flp-neomycin-Flp cassette in intron 1, a FLAG-(C)4-FLAG cassette in exon 2, and LoxP site in intron 2. Mutant protein expression levels are similar to those of the wildtype protein. Expression is brain-specific and localized in the neuronal soma and dendrites (presumably on cargo vesicles). Protein can be recognized using FLAG antibody by Western blot analysis, but not in brain sections and labeled cultures. No significant N-ethyl-maleimide-sensitive factor attachment protein receptor (SNARE) binding is observed in immunoprecipitation (IP) assays. (J:131804)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syt11 Mutation:	40 strains or lines available

Original:	J:131804 Sudhof TC, Generation of Syt11 mutant mice. MGI Direct Data Submission. 2008;
All:	4 reference(s)