Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(CAG-cre)Jphe
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jean-Paul Herman
MGI ID:	MGI:3774388
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(CAG-cre)Jphe page

Germline Transmission:	Earliest citation of germline transmission: J:130959
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    rapamycin Mutation:    Insertion   Gt(ROSA)26Sortm1(CAG-cre)Jphe expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note chicken CAG   Mutation details: The expression of a dimerizable cre was achieved by insertion of the cre60.F2 N-terminal cre moiety which is fused to FRB (the ligand binding domain of FRAP,an FKBP12-rapamycin associated protein) under the control of the endogenous promoter and a Caggs-cre59.F2 cassette, containing the C-teminal moiety of cre fused to FKBP12 (FK506-binding protein) under control of the CAG promoter, into the ROSA locus. A hygro cassette was also inserted into the locus for selection purposes. The split cre is inactive until dimerization is induced by administration of rapamycin. (J:130959)

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:130959 Jullien N, et al., Conditional Transgenesis Using Dimerizable Cre (DiCre). PLoS One. 2007;2(12):e1355
All:	1 reference(s)