Tg(Itgax-SV40T,-EGFP)2Hao
Transgene Detail
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| Symbol: |
Tg(Itgax-SV40T,-EGFP)2Hao |
| Name: |
transgene insertion 2, Hans Acha-Orbea |
| MGI ID: |
MGI:3773921 |
| Synonyms: |
Mushi2, Tg(Itgax-SV40T,EGFP)2Hao |
| Transgene: |
Tg(Itgax-SV40T,-EGFP)2Hao Location: unknown
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| Alliance: |
Tg(Itgax-SV40T,-EGFP)2Hao page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The Itgax promoter drives dendritic cell-specific expression of a floxed cassette that contains the SV40 T-antigen gene with an inserted initiation site, an inserted perfect Kozak sequence and removal of the 5' and 3' untranslated regions followed by an IRES-EGFP reporter. The intron and polyadenylation signal of rabbit beta1 globin with a 3' frt site is located between the promoter and floxed cassette. Production of multiple transgene splice products was confirmed by RT-PCR on spleen extracts.
(J:131319)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Two lines were created with the same transgene vector (Mushi1 and Mushi2). Mushi1 expresses high levels of the transgene while Mushi2 expresses low levels.
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| Original: |
J:131319 Steiner QG, et al., In vivo transformation of mouse conventional CD8{alpha}+ dendritic cells leads to progressive multisystem histiocytosis. Blood. 2008 Feb 15;111(4):2073-82 |
| All: |
1 reference(s) |
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Analysis Tools
