Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adora2btm1Dgen
Name:	adenosine A2b receptor; targeted mutation 1, Deltagen
MGI ID:	MGI:3773754
Synonyms:	A2BAR-, A2BKO
Gene:	Adora2b  Location: Chr11:62139810-62157278 bp, + strand  Genetic Position: Chr11, 37.96 cM, cytoband B2
Alliance:	Adora2btm1Dgen page

Germline Transmission:	Earliest citation of germline transmission: J:131444
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Deltagen

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A fragment from 112 bp to 267 bp of the coding region was replaced with an IRES-lacZ and neo cassette. The absence of transcript expression was confirmed by real-time RT-PCR on cardiac tissue extracts. This allele is also a null allele. (J:131444)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adora2b Mutation:	19 strains or lines available

Original:	J:131444 Eckle T, et al., Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation. 2007 Mar 27;115(12):1581-90
All:	37 reference(s)