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Tg(Tcra,Tcrb)HRCAll
Transgene Detail
Summary
Symbol: Tg(Tcra,Tcrb)HRCAll
Name: transgene insertion HRC, James P Allison
MGI ID: MGI:3773741
Synonyms: 6B1-6 TCR, HRC TCR
Transgene: Tg(Tcra,Tcrb)HRCAll  Location: unknown  
Alliance: Tg(Tcra,Tcrb)HRCAll page
Transgene
origin
Strain of Origin:  either: C57BL/6 or (CBA x C57BL/6)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tcra,Tcrb)HRCAll expresses 2 genes
 
Mutation detailsRearranged Valpha2-SGTGGYKV TCRalpha and Vbeta8.3-SGTGGSAETL TCRbeta chains were cloned from a population of CD8+ T cells that recognizes a 17-mer peptide from the C-terminus of Histone 4 family members presented on H2-Kb. The recombined gene segments were placed in a TCR expression vector and injected into blastocytes. This founder line is characterized by "complete" expression of the transgenic TCR with 98% of CD8+ T cells expressing the transgenic TCR. (J:131347)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:131347 Savage PA, et al., Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes. Science. 2008 Jan 11;319(5860):215-20
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory