Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hspa5tm1Aoe
Name:	heat shock protein 5; targeted mutation 1, Tomohiko Aoe
MGI ID:	MGI:3773635
Synonyms:	BiPdeltaKDEL
Gene:	Hspa5  Location: Chr2:34662102-34666541 bp, + strand  Genetic Position: Chr2, 22.94 cM
Alliance:	Hspa5tm1Aoe page

Germline Transmission:	Earliest citation of germline transmission: J:131209
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: The coding region for the KDEL sequence was replaced with a floxed neo cassette that was subsequently removed by germ-line, cre-mediated recombination. (J:131209)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hspa5 Mutation:	38 strains or lines available

Original:	J:131209 Mimura N, et al., Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP. Cell Death Differ. 2007 Aug;14(8):1475-85
All:	5 reference(s)