Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pbx3tm1Og
Name:	pre B cell leukemia homeobox 3; targeted mutation 1, Stephen O'Gorman
MGI ID:	MGI:3773271
Synonyms:	Pbx3C
Gene:	Pbx3  Location: Chr2:34061469-34262375 bp, - strand  Genetic Position: Chr2, 22.84 cM
Alliance:	Pbx3tm1Og page

Germline Transmission:	Earliest citation of germline transmission: J:130927
Parent Cell Line:	PC3 (ES Cell)
Strain of Origin:	129S4/SvJae-Tg(Prm-cre)70Og

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A neo cassette with a 5' loxP site was inserted into intron 3 and an additional loxP site was inserted into intron 2. Targeting took place in PC3 ES cells, which are homozygous for Tg(Prm-cre)70Og, a cre transgene active only in haploid spermatids. A minority of the alleles created from this construct exhibited a deficiency of cre-mediated recombination driven by the male-germline specific protamine promoter in male germ cells and transmitted the conditional allele through male chimeric mice. (J:130927)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pbx3 Mutation:	35 strains or lines available

Original:	J:130927 Rottkamp CA, et al., Pbx3 is required for normal locomotion and dorsal horn development. Dev Biol. 2008 Feb 1;314(1):23-39
All:	2 reference(s)