Trim24tm1.1Los
Targeted Allele Detail
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Symbol: |
Trim24tm1.1Los |
Name: |
tripartite motif-containing 24; targeted mutation 1.1, Regine Losson |
MGI ID: |
MGI:3772051 |
Synonyms: |
Trim24-, Trim24L- |
Gene: |
Trim24 Location: Chr6:37847746-37943231 bp, + strand Genetic Position: Chr6, 17.07 cM, cytoband B1
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Alliance: |
Trim24tm1.1Los page
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Germline Transmission: |
Earliest citation of germline transmission:
J:130210
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Parent Cell Line: |
D4 (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Exon 4 was floxed by introducing a loxP site upstream of the exon and inserting a loxP flanked PGK/TK neomycin cassette downstream of the exon. Chimeric mice were generated, crossed with a Cre-deleter strain and offspring were selected that had both exon 4 and the neo selection cassette removed. The deletion was also predicted to generate a frameshift mutation with a premature stop codon. Gene inactivation was confirmed by Western blot analysis of liver and testis protein.
(J:130210)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trim24 Mutation: |
98 strains or lines available
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Original: |
J:130210 Khetchoumian K, et al., Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet. 2007 Dec;39(12):1500-6 |
All: |
4 reference(s) |
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