Tg(TTR-Igf1)1Jxu
Transgene Detail
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| Symbol: |
Tg(TTR-Igf1)1Jxu |
| Name: |
transgene insertion 1, Jianming Xu |
| MGI ID: |
MGI:3771966 |
| Synonyms: |
TTR-IGF-I |
| Transgene: |
Tg(TTR-Igf1)1Jxu Location: unknown
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| Alliance: |
Tg(TTR-Igf1)1Jxu page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(TTR-Igf1)1Jxu expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Igf1 (MGI:96432) |
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Mutation details: The transgene construct consists of the enhancer/promoter of the TTR gene, the mouse Igf1 cDNA, and the SV40t polyadenylation-signaling sequence. The IGF-I transgene was flanked with a tandem repeat of the HS4 chromosomal insulator sequence from the 5' region of the chicken beta-globin gene. This line carries approximately three copies of the transgene construct. This line expresses Igf1 at 3x the endogenous level in the liver.
(J:129478)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:129478 Liao L, et al., Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency. Endocrinology. 2006 Aug;147(8):3877-88 |
| All: |
4 reference(s) |
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Analysis Tools
